Establishment of mitotic spindle localization

Across TCGA cell cohorts, RNA activity of the Establishment of mitotic spindle localization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H4-16, HMOX1, and TMEM229B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H4-16 grouped by Establishment of mitotic spindle localization-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	H4-16 →	+1.748	+0.189	<.001	<.001	3	5
PANCREAS	HMOX1 →	-1.786	-0.167	.003	.006	2	5
BREAST	TMEM229B →	+1.427	+0.110	.007	.004	3	4
SKIN	NAGK →	-0.457	-0.115	.004	.009	3	4
SOFT_TISSUE	FOXP1 →	-1.860	-0.227	.007	.001	3	4
CNS	TGFBI →	-3.215	-0.206	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H4-16 by Establishment of mitotic spindle localization activity — LUNG_SCLC

Explore this box plot interactively →