Establishment of mitotic spindle localization

Across TCGA cell cohorts, RNA activity of the Establishment of mitotic spindle localization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPV17L2, GRINA, and RAB3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of mitotic spindle localization activity versus MPV17L2 in STOMACH (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MPV17L2 →	-1.004	-0.218	<.001	<.001	3	5
BONE	GRINA →	-1.626	-0.196	.009	.007	2	5
STOMACH	RAB3A →	-1.398	-0.212	.002	.004	3	4
STOMACH	MAD2L2 →	-1.538	-0.290	.004	.004	3	4
STOMACH	EPS8L1 →	+1.970	+0.208	.007	.005	3	4
STOMACH	BCL2L1 →	+1.138	+0.204	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040001 vs MPV17L2 — STOMACH

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