Membrane fusion involved in viral entry into host cell

Across TCGA patient cohorts, RNA activity of the Membrane fusion involved in viral entry into host cell pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO_S685, SMARCC2_T322, and CSE1L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane fusion involved in viral entry into host cell activity versus SYNPO_S685 in OV (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SYNPO_S685 →	+0.580	+0.053	.008	.002	3	7
LUAD	SMARCC2_T322 →	-0.791	-0.080	.001	<.001	3	7
LSCC	CSE1L →	-0.322	-0.080	<.001	<.001	3	7
CCRCC	GAS6 →	+0.491	+0.171	<.001	<.001	3	7
CCRCC	LUM →	+0.942	+0.115	<.001	<.001	3	7
BRCA	SVIL_S467 →	+0.750	+0.076	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039663 vs SYNPO_S685 — OV

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