Membrane fusion involved in viral entry into host cell

Across TCGA patient cohorts, RNA activity of the Membrane fusion involved in viral entry into host cell pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERAP1, ACACA, and WWOX-AS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane fusion involved in viral entry into host cell activity versus ERAP1 in BRCA (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ERAP1 →	-0.347	-0.526	.006	<.001	3	3
UCEC	ACACA →	-0.420	-0.514	.006	.005	3	3
HNSC	WWOX-AS1 →	+0.575	+0.564	.002	.002	3	2
LUAD	SBDS →	-0.412	-0.439	.001	<.001	3	2
LUAD	ZFYVE28 →	+0.366	+0.501	.006	<.001	3	2
LUAD	MRGPRX2 →	-0.114	-0.398	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039663 vs ERAP1 — BRCA

Explore this scatter interactively →