Membrane fusion involved in viral entry into host cell

Across TCGA cell cohorts, RNA activity of the Membrane fusion involved in viral entry into host cell pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NECTIN2, GAS6, and CH25H, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NECTIN2 grouped by Membrane fusion involved in viral entry into host cell-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NECTIN2 →	-0.322	-1.545	<.001	<.001	3	9
BLOOD_Myeloma	GAS6 →	-0.302	-1.534	.001	.001	2	10
BREAST	CH25H →	-0.419	-1.053	.001	.002	3	8
BREAST	HYAL2 →	-0.279	-0.793	.001	.008	2	7
LUNG_SCLC	MAT1A →	-0.245	-1.400	<.001	<.001	3	5
BLOOD_Myeloma	LBR →	-0.187	-1.175	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NECTIN2 by Membrane fusion involved in viral entry into host cell activity — SOFT_TISSUE

Explore this box plot interactively →