Regulation of RIG-I signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of RIG-I signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX60, IFIT2, and NMI, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of RIG-I signaling pathway activity versus DDX60 in HNSC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DDX60 →	+0.671	+0.072	<.001	<.001	3	8
HNSC	IFIT2 →	+0.961	+0.066	<.001	<.001	3	8
OV	NMI →	+0.594	+0.065	<.001	<.001	3	8
LSCC	PSMB6 →	-0.343	-0.048	<.001	<.001	3	8
OV	GBP2 →	+0.707	+0.058	<.001	<.001	3	7
BRCA	GBP4 →	+0.555	+0.031	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039535 vs DDX60 — HNSC

Explore this scatter interactively →