Regulation of MDA-5 signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of MDA-5 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR4, ZNF365, and PDE1C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLR4 grouped by Regulation of MDA-5 signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TLR4 →	-1.930	-1.999	.009	<.001	3	3
LIVER	ZNF365 →	-1.781	-1.609	.001	.003	3	3
LIVER	PDE1C →	-3.518	-1.682	.004	<.001	3	3
LARGE_INTESTINE	SEPTIN7 →	-0.595	-0.655	<.001	.002	3	3
LARGE_INTESTINE	PEA15 →	-1.228	-0.952	.002	.006	3	3
LARGE_INTESTINE	TSC22D4 →	-0.872	-1.029	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLR4 by Regulation of MDA-5 signaling pathway activity — LIVER

Explore this box plot interactively →