Negative regulation of cytoplasmic pattern recognition receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of cytoplasmic pattern recognition receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACVR2B, PYGO1, and BTBD9-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytoplasmic pattern recognition receptor signaling pathway activity versus ACVR2B in HNSC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ACVR2B →	-0.507	-0.549	.002	<.001	3	4
LSCC	PYGO1 →	-0.775	-0.354	<.001	.007	3	4
HNSC	BTBD9-AS1 →	-0.600	-0.666	.003	<.001	3	4
UCEC	FAM66C →	-0.696	-0.368	.006	.007	3	4
CCRCC	TTC14 →	-0.395	-0.597	<.001	.003	3	4
COAD	ZNF483 →	-0.176	-0.471	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039532 vs ACVR2B — HNSC

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