Negative regulation of cytoplasmic pattern recognition receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytoplasmic pattern recognition receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VXN, TMEM30A, and SLC37A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VXN grouped by Negative regulation of cytoplasmic pattern recognition receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	VXN →	+0.149	+0.125	.002	<.001	3	4
LUNG_SCLC	TMEM30A →	+0.169	+0.274	.004	<.001	3	4
SOFT_TISSUE	SLC37A3 →	+0.426	+0.215	.007	.008	3	4
LUNG_NSCLC_LUAD	PCDHGB4 →	-0.156	-0.128	.006	.007	3	4
BLOOD_Leukemia	PWP1 →	-0.440	-0.191	.001	.005	3	4
OESOPHAGUS	POU6F2 →	-0.168	-0.215	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VXN by Negative regulation of cytoplasmic pattern recognition receptor signaling pathway activity — LUNG_NSCLC_LUAD

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