Negative regulation of cytoplasmic pattern recognition receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytoplasmic pattern recognition receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQOR, VANGL2, and MYO15A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytoplasmic pattern recognition receptor signaling pathway activity versus SQOR in OVARY (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SQOR →	-2.091	-0.151	.007	.009	3	5
STOMACH	VANGL2 →	+2.873	+0.322	.006	.001	3	5
OVARY	MYO15A →	+0.446	+0.166	.001	<.001	3	5
STOMACH	NAA40 →	+1.060	+0.274	.001	.003	3	4
STOMACH	PKD2 →	+0.912	+0.195	.009	.004	3	4
STOMACH	IFT81 →	+1.138	+0.355	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039532 vs SQOR — OVARY

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