RIG-I signaling pathway

Across TCGA patient cohorts, RNA activity of the RIG-I signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX60, NMI, and OAS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RIG-I signaling pathway activity versus DDX60 in BRCA (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX60 →	+0.538	+0.036	<.001	<.001	3	8
OV	NMI →	+0.491	+0.051	<.001	<.001	3	8
BRCA	OAS2 →	+0.864	+0.037	<.001	<.001	3	8
OV	OAS3 →	+0.594	+0.042	<.001	<.001	3	8
BRCA	IFI35 →	+0.435	+0.036	<.001	<.001	3	8
HNSC	XAF1 →	+0.671	+0.076	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039529 vs DDX60 — BRCA

Explore this scatter interactively →