RIG-I signaling pathway

Across TCGA patient cohorts, RNA activity of the RIG-I signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP2R5C, CNRIP1, and GFRA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RIG-I signaling pathway activity versus PPP2R5C in BRCA (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPP2R5C →	-0.374	-0.203	<.001	<.001	3	5
BRCA	CNRIP1 →	-0.659	-0.153	<.001	.005	3	5
GBM	GFRA2 →	-0.843	-0.110	.008	.004	3	5
OV	ZNF763 →	-0.565	-0.163	.001	<.001	3	5
LSCC	GAPDHP42 →	-0.372	-0.169	<.001	.005	3	5
PDAC	P4HB →	+0.248	+0.137	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039529 vs PPP2R5C — BRCA

Explore this scatter interactively →