RIG-I signaling pathway

Across TCGA cell cohorts, RNA activity of the RIG-I signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D5, ZFP1, and MGAT4A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RIG-I signaling pathway activity versus TBC1D5 in OESOPHAGUS (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TBC1D5 →	-1.207	-0.185	.006	.004	3	5
LIVER	ZFP1 →	-0.959	-0.240	.005	.004	2	5
BLOOD_Leukemia	MGAT4A →	-2.132	-0.130	<.001	.004	3	4
BLOOD_Leukemia	STK17B →	-1.777	-0.137	.004	.001	3	4
LUNG_SCLC	ZNF774 →	-0.797	-0.193	.002	.004	2	5
KIDNEY	LPXN →	-2.793	-0.187	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039529 vs TBC1D5 — OESOPHAGUS

Explore this scatter interactively →