TORC1 signaling

Across TCGA patient cohorts, RNA activity of the TORC1 signaling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPB41L2, RPL3, and RPL4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TORC1 signaling activity versus EPB41L2 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EPB41L2 →	+0.363	+0.024	.002	.001	3	7
BRCA	RPL3 →	-0.298	-0.025	.003	.002	2	7
BRCA	RPL4 →	-0.408	-0.032	<.001	<.001	3	6
HNSC	SEPTIN4_S432 →	+0.583	+0.065	<.001	<.001	3	6
COAD	DOCK11 →	+0.211	+0.021	.005	.005	2	7
BRCA	LRP1 →	+0.579	+0.032	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038202 vs EPB41L2 — BRCA

Explore this scatter interactively →