TORC1 signaling

Across TCGA patient cohorts, RNA activity of the TORC1 signaling pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NT5DC2, RCOR2, and REEP3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TORC1 signaling activity versus NT5DC2 in HNSC (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NT5DC2 →	-0.581	-0.144	.005	<.001	3	3
BRCA	RCOR2 →	-1.005	-0.144	.002	.006	3	3
UCEC	REEP3 →	-0.489	-0.203	<.001	<.001	3	3
PDAC	SPIN2B →	+0.217	+0.109	<.001	.002	3	3
PDAC	LINC02017 →	-0.143	-0.103	.009	.006	3	3
OV	EPAS1 →	-0.661	-0.093	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038202 vs NT5DC2 — HNSC

Explore this scatter interactively →