TORC1 signaling

Across TCGA cell cohorts, RNA activity of the TORC1 signaling pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ODC1, KLHL3, and KIAA0040, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TORC1 signaling activity versus ODC1 in BREAST (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ODC1 →	-1.482	-0.587	.001	.006	3	6
OVARY	KLHL3 →	+0.943	+0.243	.001	.001	3	5
STOMACH	KIAA0040 →	+2.975	+0.384	.004	<.001	3	5
SKIN	PGAP3 →	+0.479	+0.238	.002	<.001	3	5
SKIN	DDX1 →	-0.540	-0.260	.006	.001	3	5
BREAST	BOLA3 →	-0.709	-0.690	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038202 vs ODC1 — BREAST

Explore this scatter interactively →