Bile acid signaling pathway

Across TCGA patient cohorts, RNA activity of the Bile acid signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AX, LIG1, and KPNB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bile acid signaling pathway activity versus H2AX in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	H2AX →	-0.709	-0.677	.001	<.001	3	4
BRCA	LIG1 →	-0.496	-0.714	<.001	<.001	3	3
LSCC	KPNB1 →	-0.332	-0.350	.002	.006	3	3
BRCA	TUBG1 →	-0.379	-0.414	.003	.006	3	3
BRCA	NEMP1 →	-0.283	-0.449	.007	.002	3	3
BRCA	DEPDC1 →	-0.651	-0.458	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038183 vs H2AX — BRCA

Explore this scatter interactively →