Bile acid signaling pathway

Across TCGA cell cohorts, RNA activity of the Bile acid signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC9B, JAZF1, and IL7R, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC9B grouped by Bile acid signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCDC9B →	-2.838	-1.034	.001	.001	3	5
STOMACH	JAZF1 →	-1.548	-1.181	.007	.001	3	5
BREAST	IL7R →	-1.580	-0.871	.001	<.001	3	5
SKIN	PHLDB2 →	-2.065	-0.856	<.001	.002	3	5
LIVER	TOX2 →	-3.139	-1.715	<.001	<.001	3	4
LIVER	JPH2 →	-2.291	-1.442	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC9B by Bile acid signaling pathway activity — SOFT_TISSUE

Explore this box plot interactively →