Thrombopoietin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Thrombopoietin-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM15, CIB1, and FOXO3B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM15 grouped by Thrombopoietin-mediated signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RBM15 →	-0.330	-1.426	<.001	<.001	3	10
SKIN	CIB1 →	-0.211	-1.097	.006	.002	3	8
LUNG_NSCLC_LUAD	FOXO3B →	+0.186	+1.057	.001	<.001	3	4
OVARY	THPO →	-0.311	-1.433	<.001	<.001	3	4
OESOPHAGUS	FAM171B →	-0.317	-1.047	.008	.009	3	4
LUNG_NSCLC_LUSC	GALNT12 →	+0.173	+1.775	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM15 by Thrombopoietin-mediated signaling pathway activity — CNS

Explore this box plot interactively →