Interleukin-3-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-3-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR1B, SCIMP, and TFEC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-3-mediated signaling pathway activity versus FCGR1B in GBM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR1B →	+0.742	+0.244	<.001	<.001	3	8
UCEC	SCIMP →	+0.708	+0.754	<.001	<.001	3	8
HNSC	TFEC →	+0.989	+1.014	<.001	<.001	3	8
BRCA	IGSF6 →	+0.462	+0.409	.001	.009	3	8
HNSC	APBB1IP →	+1.101	+0.981	<.001	<.001	3	8
GBM	GPR65 →	+0.650	+0.202	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038156 vs FCGR1B — GBM

Explore this scatter interactively →