Interleukin-3-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-3-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYK, CSF2RB, and FCER1G, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYK grouped by Interleukin-3-mediated signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SYK →	-0.414	-1.162	.005	.003	3	11
LIVER	CSF2RB →	-0.220	-1.430	.003	.003	3	8
CNS	FCER1G →	-0.193	-1.052	<.001	<.001	3	7
KIDNEY	STAT5A →	-0.209	-1.300	.009	.008	2	6
LARGE_INTESTINE	SFTPA1 →	+0.124	+1.140	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	GLRX →	-0.120	-1.105	.009	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYK by Interleukin-3-mediated signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →