Interleukin-3-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-3-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIL2, PVALB, and ACIN1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPIL2 grouped by Interleukin-3-mediated signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPIL2 →	-0.375	-1.923	.009	.002	1	1
BLOOD_Leukemia	PVALB →	+0.175	+1.923	.007	.002	1	1
BLOOD_Leukemia	ACIN1 →	-0.345	-1.923	.003	.002	1	1
BLOOD_Leukemia	APEX1 →	+0.125	+1.923	.007	.002	1	1
BLOOD_Leukemia	SEC23A →	+0.190	+1.923	.006	.002	1	1
BLOOD_Leukemia	PLCB4 →	+0.079	+1.923	.007	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPIL2 by Interleukin-3-mediated signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →