Interleukin-3-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-3-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP2, HNF4G, and ANOS1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-3-mediated signaling pathway activity versus BMP2 in BLOOD_Leukemia (Pearson r = 0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BMP2 →	+1.953	+2.019	.003	<.001	3	1
BLOOD_Leukemia	HNF4G →	+2.746	+2.019	.007	<.001	3	1
BLOOD_Leukemia	ANOS1 →	+3.096	+2.075	<.001	<.001	2	1
BLOOD_Leukemia	PLPPR4 →	+0.211	+1.958	.001	<.001	2	1
BLOOD_Leukemia	DNAH7 →	+0.355	+2.060	<.001	<.001	2	1
BLOOD_Leukemia	PHF24 →	+0.231	+2.083	.006	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038156 vs BMP2 — BLOOD_Leukemia

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