Chemokine (C-X-C motif) ligand 12 signaling pathway

Across TCGA patient cohorts, RNA activity of the Chemokine (C-X-C motif) ligand 12 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGCD, SYNPO2_S930, and TBC1D2B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chemokine (C-X-C motif) ligand 12 signaling pathway activity versus SGCD in HNSC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SGCD →	+0.787	+0.129	<.001	<.001	3	10
LSCC	SYNPO2_S930 →	+1.248	+0.125	<.001	<.001	3	10
GBM	TBC1D2B →	+0.408	+0.105	<.001	<.001	3	10
OV	TNS2_S102 →	+0.697	+0.052	.007	.009	3	10
COAD	COLEC12 →	+0.975	+0.099	<.001	<.001	3	10
BRCA	COPZ2 →	+0.673	+0.078	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038146 vs SGCD — HNSC

Explore this scatter interactively →