ERBB4-ERBB4 signaling pathway

Across TCGA patient cohorts, RNA activity of the ERBB4-ERBB4 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are USP39_S82, HSP90B1, and WIPF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB4-ERBB4 signaling pathway activity versus USP39_S82 in LSCC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	USP39_S82 →	-0.326	-0.550	<.001	.003	3	5
COAD	HSP90B1 →	-0.151	-0.085	.009	<.001	3	5
BRCA	WIPF2 →	+0.366	+0.218	<.001	.003	3	4
COAD	CKAP4 →	-0.435	-0.114	<.001	.002	3	4
BRCA	AGR3 →	+0.901	+0.266	<.001	.005	3	4
BRCA	DDAH1 →	+0.505	+0.151	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038138 vs USP39_S82 — LSCC

Explore this scatter interactively →