ERBB4-ERBB4 signaling pathway

Across TCGA patient cohorts, RNA activity of the ERBB4-ERBB4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD69, CYTIP, and EPB41L3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB4-ERBB4 signaling pathway activity versus CD69 in LSCC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD69 →	-0.827	-0.243	.005	<.001	3	5
OV	CYTIP →	-0.801	-0.185	<.001	<.001	3	4
LSCC	EPB41L3 →	-0.955	-0.268	<.001	<.001	3	4
LUAD	S1PR1 →	-1.084	-0.326	.009	<.001	2	4
OV	PTPN7 →	-0.679	-0.231	.001	<.001	3	3
OV	RASSF2 →	-0.760	-0.196	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038138 vs CD69 — LSCC

Explore this scatter interactively →