ERBB2-ERBB4 signaling pathway

Across TCGA patient cohorts, RNA activity of the ERBB2-ERBB4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERBB2, PGAP3, and TIAL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB2-ERBB4 signaling pathway activity versus ERBB2 in BRCA (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ERBB2 →	+1.281	+0.672	<.001	<.001	3	5
BRCA	PGAP3 →	+0.959	+0.552	<.001	<.001	3	4
GBM	TIAL1 →	-0.277	-0.251	.001	.001	3	4
GBM	ZBTB8B →	-0.434	-0.210	.004	.007	3	4
OV	RFC4 →	-0.638	-0.412	.001	.001	3	3
COAD	ATPAF2 →	-0.256	-0.361	.003	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038135 vs ERBB2 — BRCA

Explore this scatter interactively →