ERBB3 signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB3 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCN3, ELAVL1, and CIAPIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB3 signaling pathway activity versus CLCN3 in BREAST (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CLCN3 →	+0.980	+1.432	<.001	<.001	3	5
PANCREAS	ELAVL1 →	+0.678	+1.307	.003	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CIAPIN1 →	+1.058	+1.453	.003	.001	3	5
OESOPHAGUS	WASL →	+0.891	+1.046	.003	.006	3	4
OESOPHAGUS	CD164 →	+0.801	+0.985	<.001	<.001	3	4
OESOPHAGUS	MRPL24 →	+0.741	+1.063	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038129 vs CLCN3 — BREAST

Explore this scatter interactively →