ERBB2 signaling pathway

Across TCGA patient cohorts, RNA activity of the ERBB2 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SSH3_S484, EGFR, and CLTB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB2 signaling pathway activity versus SSH3_S484 in HNSC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SSH3_S484 →	+0.528	+0.161	<.001	<.001	3	6
GBM	EGFR →	+1.447	+0.095	<.001	<.001	3	6
HNSC	CLTB →	+0.329	+0.101	<.001	<.001	3	5
OV	CARMIL2_S1381 →	-1.163	-0.056	.008	<.001	3	5
HNSC	ACOT11 →	+0.673	+0.112	<.001	<.001	3	5
LSCC	BAIAP2L1 →	+0.448	+0.080	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038128 vs SSH3_S484 — HNSC

Explore this scatter interactively →