ERBB2 signaling pathway

Across TCGA patient cohorts, RNA activity of the ERBB2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTK6, B3GNT3, and IYD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB2 signaling pathway activity versus PTK6 in HNSC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PTK6 →	+1.091	+0.420	<.001	.001	3	5
OV	B3GNT3 →	+1.392	+0.751	<.001	<.001	3	4
CCRCC	IYD →	+0.888	+0.396	.001	.005	3	4
LSCC	HSPB1 →	+0.725	+0.465	<.001	.007	3	4
GBM	C10orf88 →	-0.292	-0.342	<.001	.005	3	4
LUAD	PDE3B →	-0.698	-0.489	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038128 vs PTK6 — HNSC

Explore this scatter interactively →