ERBB2 signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAP1L1, C12orf4, and ITPRIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NAP1L1 grouped by ERBB2 signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NAP1L1 →	-0.718	-1.167	.001	<.001	3	5
LARGE_INTESTINE	C12orf4 →	-0.502	-0.382	.004	.005	3	4
LUNG_NSCLC_LUAD	ITPRIP →	-0.899	-0.684	.004	<.001	3	4
BLOOD_Leukemia	SLC35A5 →	-0.609	-0.726	.004	.004	3	4
BREAST	NNT →	-1.595	-0.980	.003	.001	3	4
BREAST	TMEM126B →	-0.831	-0.952	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NAP1L1 by ERBB2 signaling pathway activity — BREAST

Explore this box plot interactively →