ERBB2 signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBY1, PPP4R4, and RAB1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB2 signaling pathway activity versus CBY1 in SKIN (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CBY1 →	+0.870	+0.995	.001	.004	3	5
LUNG_NSCLC_LUSC	PPP4R4 →	+2.286	+1.063	<.001	.008	3	5
BLOOD_Leukemia	RAB1B →	+0.311	+0.605	.007	.007	3	5
CNS	EGFR →	+2.114	+1.325	<.001	<.001	3	4
CNS	SFXN1 →	+0.489	+0.727	.005	.003	3	4
LARGE_INTESTINE	MOB3A →	+0.944	+1.038	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038128 vs CBY1 — SKIN

Explore this scatter interactively →