Interleukin-2-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-2-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMSN1_S23, SPN, and STK4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-2-mediated signaling pathway activity versus SAMSN1_S23 in BRCA (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SAMSN1_S23 →	+0.753	+0.083	.006	.001	3	10
OV	SPN →	+0.787	+0.066	<.001	<.001	3	10
HNSC	STK4 →	+0.393	+0.122	<.001	<.001	3	10
UCEC	TYMP →	+0.675	+0.123	<.001	<.001	3	10
GBM	WAS →	+0.588	+0.113	<.001	<.001	3	10
HNSC	WIPF1 →	+0.381	+0.139	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038110 vs SAMSN1_S23 — BRCA

Explore this scatter interactively →