Interleukin-2-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-2-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPP1, RPL37A, and LILRB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-2-mediated signaling pathway activity versus MPP1 in GBM (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MPP1 →	+0.407	+0.172	<.001	<.001	3	4
LSCC	RPL37A →	-0.360	-0.180	.002	.006	3	4
BRCA	LILRB2 →	+0.740	+0.487	<.001	<.001	3	4
BRCA	MYO1G →	+0.678	+0.520	.001	<.001	3	4
BRCA	ARRB2 →	+0.310	+0.298	.001	.002	3	4
BRCA	TRAV17 →	+0.773	+0.355	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038110 vs MPP1 — GBM

Explore this scatter interactively →