Vascular endothelial growth factor signaling pathway

Across TCGA patient cohorts, RNA activity of the Vascular endothelial growth factor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP3, JAM2, and CALHM5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular endothelial growth factor signaling pathway activity versus TIMP3 in COAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TIMP3 →	+1.282	+1.133	<.001	<.001	3	8
CCRCC	JAM2 →	+0.748	+0.785	<.001	.001	3	8
OV	CALHM5 →	+0.969	+0.400	<.001	<.001	3	8
OV	LHFPL6 →	+1.064	+0.272	<.001	<.001	3	8
OV	PRKG1 →	+1.147	+0.493	<.001	<.001	3	8
COAD	FERMT2 →	+1.076	+1.409	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038084 vs TIMP3 — COAD

Explore this scatter interactively →