Vascular endothelial growth factor signaling pathway

Across TCGA cell cohorts, RNA activity of the Vascular endothelial growth factor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VGF, BNIP3L, and PPP2R2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VGF grouped by Vascular endothelial growth factor signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VGF →	-1.801	-0.472	.004	.001	3	4
LUNG_NSCLC_LUAD	BNIP3L →	-0.806	-0.224	.006	.007	3	3
LUNG_NSCLC_LUAD	PPP2R2A →	-0.648	-0.325	<.001	<.001	3	3
LUNG_SCLC	IGFBP5 →	-5.867	-0.318	<.001	.002	3	3
LUNG_SCLC	CDKAL1 →	-1.773	-0.362	.001	.001	3	3
LIVER	LRFN4 →	+1.900	+0.239	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VGF by Vascular endothelial growth factor signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →