Vascular endothelial growth factor signaling pathway

Across TCGA cell cohorts, RNA activity of the Vascular endothelial growth factor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R18, IL6ST, and CCN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular endothelial growth factor signaling pathway activity versus PPP1R18 in LUNG_SCLC (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PPP1R18 →	+1.398	+1.305	.003	<.001	3	6
BONE	IL6ST →	+1.846	+1.238	<.001	.009	2	6
BREAST	CCN1 →	+1.863	+0.858	.004	<.001	3	5
BREAST	AXL →	+2.587	+0.723	.005	.006	3	5
BREAST	SNX33 →	+0.792	+0.940	.004	.004	3	5
BREAST	FAM114A1 →	+2.148	+1.282	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038084 vs PPP1R18 — LUNG_SCLC

Explore this scatter interactively →