Collagen-activated signaling pathway

Across TCGA cell cohorts, RNA activity of the Collagen-activated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FADS2, QARS1, and HRK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FADS2 grouped by Collagen-activated signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FADS2 →	-0.207	-1.129	.001	.002	3	4
BLOOD_Leukemia	QARS1 →	+0.187	+0.637	.007	.007	3	4
SOFT_TISSUE	HRK →	+0.308	+0.306	.007	.002	3	4
SOFT_TISSUE	DENND2B →	-0.366	-0.395	<.001	<.001	3	4
SKIN	YIPF1 →	+0.327	+0.146	<.001	.007	3	4
PANCREAS	DPYSL3 →	-0.180	-0.243	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FADS2 by Collagen-activated signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →