Collagen-activated tyrosine kinase receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Collagen-activated tyrosine kinase receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCYL1, MRPL49, and FAM161B, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collagen-activated tyrosine kinase receptor signaling pathway activity versus SCYL1 in CNS (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SCYL1 →	-0.645	-1.764	<.001	<.001	3	2
CNS	MRPL49 →	-0.666	-1.764	.001	<.001	3	2
CNS	FAM161B →	-0.606	-1.830	.009	.001	3	2
CNS	RAB6A →	-0.660	-1.982	.004	<.001	3	2
CNS	REX1BD →	+0.737	+1.764	.004	<.001	3	2
SKIN	HAX1 →	+0.644	+1.588	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038063 vs SCYL1 — CNS

Explore this scatter interactively →