Interleukin-5-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-5-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S179, and SKAP2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-5-mediated signaling pathway activity versus RCSD1 in GBM (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.635	+0.153	<.001	<.001	3	10
HNSC	RCSD1_S179 →	+0.735	+0.121	<.001	<.001	3	10
GBM	SKAP2 →	+0.803	+0.145	<.001	<.001	3	10
OV	SPN →	+0.838	+0.104	<.001	<.001	3	10
OV	SPN_S355 →	+0.786	+0.066	.004	.009	3	10
OV	SPN_S368 →	+1.203	+0.089	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038043 vs RCSD1 — GBM

Explore this scatter interactively →