Interleukin-5-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-5-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-DQB1-AS1, AKNA, and BIN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-5-mediated signaling pathway activity versus HLA-DQB1-AS1 in CCRCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HLA-DQB1-AS1 →	+0.650	+0.348	<.001	.006	3	7
CCRCC	AKNA →	+0.485	+0.795	<.001	<.001	3	6
CCRCC	BIN2 →	+0.600	+0.487	<.001	<.001	3	6
CCRCC	WDFY4 →	+0.642	+0.550	<.001	<.001	3	6
BRCA	FGD2 →	+0.508	+0.761	.001	<.001	3	6
CCRCC	SCIMP →	+0.569	+0.565	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038043 vs HLA-DQB1-AS1 — CCRCC

Explore this scatter interactively →