Apolipoprotein A-I-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Apolipoprotein A-I-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ABCA1_S1296, FOXC1_S241, and IKBIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apolipoprotein A-I-mediated signaling pathway activity versus ABCA1_S1296 in UCEC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ABCA1_S1296 →	+0.616	+0.067	<.001	.001	3	5
LUAD	FOXC1_S241 →	+1.026	+0.095	<.001	.001	3	4
CCRCC	IKBIP →	+0.401	+0.052	<.001	<.001	3	4
HNSC	SCAF4 →	-0.187	-0.063	.005	.007	2	4
UCEC	CHPF2_S64 →	+0.512	+0.130	.002	.005	3	3
BRCA	AP2A1 →	+0.169	+0.038	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038027 vs ABCA1_S1296 — UCEC

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