Apolipoprotein A-I-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Apolipoprotein A-I-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOSL2, LAS1L, and SMIM4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOSL2 grouped by Apolipoprotein A-I-mediated signaling pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FOSL2 →	+2.902	+1.529	.005	<.001	3	6
BLOOD_Leukemia	LAS1L →	+0.495	+1.106	.002	.005	2	6
BONE	SMIM4 →	+1.209	+1.388	<.001	.002	3	5
OVARY	PRICKLE1 →	+1.594	+1.203	.002	.002	3	5
BONE	HACD1 →	+1.873	+1.566	<.001	<.001	3	5
BONE	DENND5B →	+1.315	+1.566	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOSL2 by Apolipoprotein A-I-mediated signaling pathway activity — BONE

Explore this box plot interactively →