Apolipoprotein A-I-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Apolipoprotein A-I-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A23, RAD50, and TIMP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A23 grouped by Apolipoprotein A-I-mediated signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC25A23 →	-0.235	-0.234	<.001	.001	3	3
SKIN	RAD50 →	-0.210	-0.238	.002	.001	3	3
CNS	TIMP1 →	-0.299	-0.225	.005	.004	3	3
BREAST	NQO2 →	+0.144	+0.313	<.001	.001	3	3
SKIN	FOXJ3 →	+0.132	+0.269	<.001	<.001	3	2
BREAST	RAB7A →	+0.279	+0.434	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A23 by Apolipoprotein A-I-mediated signaling pathway activity — OVARY

Explore this box plot interactively →