Apolipoprotein A-I-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Apolipoprotein A-I-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL12A1, DDX60, and EIF2B3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apolipoprotein A-I-mediated signaling pathway activity versus COL12A1 in PANCREAS (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	COL12A1 →	+3.931	+0.336	.007	.002	3	4
SKIN	DDX60 →	+0.852	+0.267	.006	<.001	3	4
URINARY_TRACT	EIF2B3 →	-0.890	-0.344	.006	.008	2	4
LUNG_SCLC	TMEM9B →	+1.230	+0.344	.006	.003	3	3
LUNG_SCLC	SCARF1 →	+0.314	+0.367	.008	.003	2	4
PANCREAS	KITLG →	+2.364	+0.336	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038027 vs COL12A1 — PANCREAS

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