Reelin-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Reelin-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRCC, SUPT20H, and BRMS1_S237, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reelin-mediated signaling pathway activity versus PRCC in BRCA (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRCC →	+0.302	+0.062	<.001	<.001	3	6
BRCA	SUPT20H →	+0.262	+0.068	.002	<.001	3	5
LUAD	BRMS1_S237 →	+0.490	+0.047	.004	.008	3	5
BRCA	DYNC1LI2 →	-0.213	-0.040	.001	.008	3	4
PDAC	MAPK1IP1L →	-0.340	-0.032	<.001	.001	2	5
BRCA	NOP56 →	+0.289	+0.038	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038026 vs PRCC — BRCA

Explore this scatter interactively →