Reelin-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Reelin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIAM2, RPL9P16, and STAG3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reelin-mediated signaling pathway activity versus TIAM2 in PDAC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TIAM2 →	+0.345	+0.636	<.001	<.001	3	3
PDAC	RPL9P16 →	+0.502	+0.502	<.001	<.001	3	3
PDAC	STAG3 →	+0.266	+0.587	.002	<.001	3	3
PDAC	ACOT7 →	-0.459	-0.510	.003	.008	3	3
UCEC	RMDN2-AS1 →	+0.389	+0.303	.002	.008	2	4
UCEC	PRDX3P4 →	+0.730	+0.463	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038026 vs TIAM2 — PDAC

Explore this scatter interactively →