Reelin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Reelin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNASEK, RAN, and STIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNASEK grouped by Reelin-mediated signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RNASEK →	-1.257	-0.404	.001	.009	2	5
STOMACH	RAN →	+0.762	+0.232	.002	.007	3	4
KIDNEY	STIP1 →	+0.904	+1.522	.008	.001	3	4
BLOOD_Myeloma	RRP15 →	+1.510	+0.328	.004	.002	3	4
BLOOD_Myeloma	HNRNPCL1 →	+0.142	+0.346	.003	.001	3	4
BLOOD_Myeloma	MRPL3 →	+0.631	+0.265	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNASEK by Reelin-mediated signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →