Reelin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Reelin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP8, CUL5, and AGO1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reelin-mediated signaling pathway activity versus LRP8 in BREAST (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LRP8 →	+1.566	+0.129	<.001	.001	3	12
BLOOD_Leukemia	CUL5 →	+0.833	+0.121	<.001	<.001	3	10
LARGE_INTESTINE	AGO1 →	+0.806	+0.090	.001	.006	3	9
BLOOD_Myeloma	CHST10 →	+2.072	+0.131	<.001	<.001	3	8
URINARY_TRACT	POU6F1 →	+1.138	+0.107	<.001	<.001	3	8
URINARY_TRACT	MAFG →	+1.127	+0.146	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038026 vs LRP8 — BREAST

Explore this scatter interactively →