Reelin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Reelin-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XKRX, FBXO11, and MBD6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XKRX grouped by Reelin-mediated signaling pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	XKRX →	+0.197	+1.521	.008	<.001	3	4
LARGE_INTESTINE	FBXO11 →	-0.292	-0.891	<.001	<.001	3	4
STOMACH	MBD6 →	+0.207	+1.688	.003	<.001	3	3
LUNG_NSCLC_LUSC	MTG2 →	-0.230	-1.884	.005	.007	3	3
LIVER	LY6E →	-0.128	-1.405	<.001	.001	3	3
OVARY	H4-16 →	-0.238	-1.047	.006	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XKRX by Reelin-mediated signaling pathway activity — STOMACH

Explore this box plot interactively →